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Nick Cannon's 5-Month-Old Son Died of Brain Cancer After a Tumor Caused Fluid Buildup in His Brain

Nick Cannon shared devastating news with fans earlier today: His 5-month-old son, Zen Scott Cannon, has died from a brain tumor.

"Over the weekend I lost my youngest son to a condition called hydrocephalus. That is pretty much a malignant, midline brain tumor—brain cancer," Cannon said on The Nick Cannon Show, as reported by NBC News. Zen, Cannon's seventh child, was diagnosed after his father noticed that he had a cough.

According to Cannon, he always noticed his son had a "sinus thing"—he explained it as a cough. Initially, he thought it was some sort of fluid in the baby's lungs that would eventually get coughed out. "He always had this real interesting breathing and by the time he was two months old I noticed…he had a nice-sized head—I called it a Cannon head," he said, referencing the larger shape of his other kids' heads. "We didn't think anything about it," he said. "But I really wanted to take him to the doctor to get the breathing and the sinus things checked out, so we thought it would be a routine process."

Cannon shared that the doctors said his son's sinuses looked good, but the infant actually had another condition. "There was fluid that was building up in his head, and that was the cause of [why] his head was starting to get big," Cannon said.

The root cause of that fluid, Cannon said, was a malignant (i.e., cancerous) brain tumor in Zen's head. "Immediately, we had to have surgery…we put a shunt in his head and we were hoping for the best," Cannon said, explaining that the shunt was put in place to drain the fluid out "so his head would be normal and he would be able to function."

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Cannon said that an "interesting turn" came around Thanksgiving of this year. "The process sped up…and the tumor began to grow a lot faster," he said.

Because of that, Cannon said he "made an effort to spend the most quality time with Zen" over the weekend—during which he was able to hold his son for the last time. "Not only did we get to see the sunrise, but we got to see the sunset, too," Cannon said.

"I didn't know how I was going to handle today," he continued, as he made his announcement on his eponymous talk show. "But I wanted to grieve with my family." Cannon also took a moment to thank Zen's mom, Alyssa, for being "the strongest woman I've ever seen."

Cannon's news raises a lot of questions about hydrocephalus, and how a brain tumor can lead to the condition. Here's what you need to know.

What is hydrocephalus, and why is it so dangerous?

Hydrocephalus is an abnormal buildup of fluid in the ventricles (i.e. cavities) within the brain, according to the National Institute of Neurological Disorders and Stroke (NINDS). That extra fluid forces the ventricles to widen and puts pressure on the brain's tissues.

Under normal circumstances, cerebrospinal fluid (the clear, colorless fluid that protects and cushions the brain and spine) flows through the ventricles, brain, and spinal cord, before being absorbed into the bloodstream, the NINDS explains. But, when it's blocked, the fluid can build up and keep the brain from functioning.

That can lead to brain damage and even death. "Your brain needs to have blood and oxygen to survive and, when there's a blockage of the spinal fluid, it increases the intracranial pressure," Charles C. Park, MD, PhD, director of The Minimally Invasive Brain and Spine Center at Mercy Medical Center, tells Health. "Then, your brain is not getting enough oxygen and that's when it's deadly."

It's difficult to know exactly how many people are typically affected by the condition, given that it has various causes and can happen in children and adults. But a 2008 data review published in the Journal of Neurosurgery: Pediatrics estimated that, in 2003, hydrocephalus made up 0.6% of all pediatric hospitalizations in the US

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What are the symptoms of hydrocephalus?

Symptoms can vary, depending on a person's age. The NINDS says infants; children, young adults, and middle-aged adults; and older adults may all present differently when they have hydrocephalus.

Symptoms of hydrocephalus in infants:

  • A rapid increase in head size
  • An unusually large head
  • A bulge on the soft spot on the top of the head
  • Vomiting
  • Problems sucking or feeding
  • Sleepiness
  • Irritability
  • Eyes that are fixed downward or are not able to turn outward
  • Seizures

Symptoms of hydrocephalus in children, young adults, and middle-aged adults:

Symptoms of hydrocephalus in older adults:

  • Problems walking
  • Progressive mental impairment and dementia
  • General slowing of movements
  • Loss of bladder control and/or frequent urination
  • Poor coordination and balance

Dr. Parks says that it's "very common" for an infant with hydrocephalus to have heads that appear larger than those of other babies, which is what Cannon noticed in his own infant. "In babies, the cranial sutures in the skull have not formed yet," he explains. "The babies have the ability to expand their skull, and that's why the head becomes big."

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What causes hydrocephalus?

According to Cannon, his infant son's hydrocephalus resulted from a malignant brain tumor—and the NINDS says brain or spinal cord tumors can increase a person's risk of developing a type of hydrocephalus called acquired hydrocephalus. As UCSF Health reports, hydrocephalus can occur when a brain tumor blocks the flow of cerebrospinal fluid, causing a buildup of the fluid in the ventricles of the brain.

Brain tumors aren't the only cause of hydrocephalus. The NINDS says hydrocephalus can either be present at birth or shortly after delivery (congenital hydrocephalus), or it can develop over time as a result of injury or disease (acquired hydrocephalus). Both types of hydrocephalus have different causes or risk factors, per the NINDS.

Causes of congenital hydrocephalus:

  • Inherited genetic abnormalities that block the flow of cerebrospinal fluid
  • Developmental disorders such as those associated with birth defects in the brain, spine, or spinal cord
  • Complications of premature birth such as bleeding within the ventricles
  • Infection during pregnancy (like rubella) that can cause inflammation in fetal brain tissue

Risk factors for acquired hydrocephalus:

  • Brain or spinal cord tumors
  • Infections of the central nervous system such as bacterial meningitis
  • Injury or stroke that causes bleeding in the brain

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How is hydrocephalus treated—and what’s the prognosis?

There are two surgical treatments specifically for hydrocephalus, per the NINDS. The first is a shunt, which is a tube inserted into the brain to drain excess fluid out of the brain and into the chest cavity or abdomen, allowing it to be absorbed into the body. The other option is a procedure called an endoscopic third ventriculostomy (ETV), which entails placing a tiny hole at the bottom of the third ventricle of the brain so cerebrospinal fluid can drain more easily.

But if something like a tumor is causing hydrocephalus, treatment gets trickier. "Hydrocephalus is usually very treatable with a shunt, but a tumor may not be treatable," Santosh Kesari, MD, PhD, neuro-oncologist and director of neuro-oncology at Providence Saint John's Health Center and chair of the Department of Translational Neurosciences and Neurotherapeutics at Saint John's Cancer Institute, tells Health. When a tumor is present, "hydrocephalus can sometimes be fixed by shrinking the tumor," he adds.

If it's left untreated—or if the underlying cause of hydrocephalus can't be remedied—the condition can be fatal. "[Hydrocephalus] can be deadly as the brain is enclosed in the skull and cannot move if pressure is applied," Adam Esbenshade MD, chair of pediatric hematology/oncology at Vanderbilt University Medical Center, tells Health. "If the pressure gets high enough, then the brain can't do its normal function."

For uncomplicated cases in which hydrocephalus can be successfully treated, the NINDS says people can recover "almost completely" and go on to have a good quality of life.

Cannon ended his announcement by dedicating the show to his "beautiful son, Z," and offered empathy to those who have gone through or are currently going through similar situations. "You never know what somebody's going through," he said. "Hug your people, hug your family, kiss somebody, tell them you love them."

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